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KMID : 0363320010220020127
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Journal of Korean Oriental Internal Medicine
2001 Volume.22 No. 2 p.127 ~ p.134
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The Effects of Samwha-tang Extracts on Reversible Forebrain Ischemia Experimentally Induced from the Occlusion of Middle Cerebral Artery
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Kim Dong-Eun
Jeong Seung-Hyun
Park In-Sik
Shin Gil-Cho
Lee Won-Chul
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Abstract
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The purpose of this investigation is to evaluate the effects of Samwha-tang(三化湯) Extracts on reversible forebrain ischemia experimentally induced from the occlusion of middle cerebral artery. The volume of cerebral ischemia, the volume of cerebral edema, and the change of pyramidal neuron of the CA1 area in hippocampus through light microscopy were investigated.
we obtained the following results. The volume of the control group, which had ischemic damage was 21%, and the volume of the sample group, which had ischemic damage, was 16%. The ratio of the volume of the right/left hemisphere was 117.2 in the control group, and 108.8 in the sample group. Also, the light microscopy revealed that the pyramidal cells of CA1 area in hippocampus had many damages like changes into discontinuous and unsystematic forms. But, in the sample group, the cells were less damaged compared with the control group.
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KEYWORD
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Samwha-tang, brain ischemia
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